Resultado da pesquisa (1)
Termo utilizado na pesquisa Siqueira Júnior J.P.
#1 - Eliminação de resistência a drogas por fluorquinolonas em Staphylococcus aureus de origem bovina
Abstract in English:
Pereira M.S.V., Siqueira Júnior J.P. & Campos Takaki G.M. 2004. [Elimination of resistance to drugs by fluoroquinolones in bovine strains of Staphylococcus aureus.] Eliminação de resistência a drogas por fluorquinolonas em Staphylococcus aureus de origem bovina. Pesquisa Veterinária Brasileira 24(1):11-14. Depto Biologia Molecular, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraiba, João Pessoa, PB 58059-900, Brazil. E-mail: svieira@dbm.ufpb.br
Bovine strains of Staphylococcus aureus were submitted to treatment with four fluoro-quinolones in subinhibitory concentrations (1/2 x MICs) to evaluate their influence on the curing of plasmids. Ciprofloxacin showed to be the most efficient by eliminating resistance to streptomycin, tetracyclin, penicillin, and cadmium nitrate. Norfloxacin and pefloxacin eliminated penicillin- and tetracyclin-resistance respectively. Otherwise, plasmids elimination by ofloxacin was not evidenced. The results obtained in this study confirm the potential of fluoroquinolones to eliminate antibiotic-resistant plasmids, and showed to be a valuable contribution for the prevention of multi-resistant strains, and may even enhance their sensitivity to other chemotherapeutic agents.
Abstract in Portuguese:
Pereira M.S.V., Siqueira Júnior J.P. & Campos Takaki G.M. 2004. [Elimination of resistance to drugs by fluoroquinolones in bovine strains of Staphylococcus aureus.] Eliminação de resistência a drogas por fluorquinolonas em Staphylococcus aureus de origem bovina. Pesquisa Veterinária Brasileira 24(1):11-14. Depto Biologia Molecular, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraiba, João Pessoa, PB 58059-900, Brazil. E-mail: svieira@dbm.ufpb.br
Bovine strains of Staphylococcus aureus were submitted to treatment with four fluoro-quinolones in subinhibitory concentrations (1/2 x MICs) to evaluate their influence on the curing of plasmids. Ciprofloxacin showed to be the most efficient by eliminating resistance to streptomycin, tetracyclin, penicillin, and cadmium nitrate. Norfloxacin and pefloxacin eliminated penicillin- and tetracyclin-resistance respectively. Otherwise, plasmids elimination by ofloxacin was not evidenced. The results obtained in this study confirm the potential of fluoroquinolones to eliminate antibiotic-resistant plasmids, and showed to be a valuable contribution for the prevention of multi-resistant strains, and may even enhance their sensitivity to other chemotherapeutic agents.
